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目的:分析苏州市某中医医院β-内酰胺类抗生素及其复合制剂的临床使用的相关因素,为临床合理使用此类药物提供参考。方法:采用回顾性分析,统计2005年—2009年该院β-内酰胺类抗生素及其复合制剂使用的品种、规格、剂型、销售数量和总金额,对金额排序和用药频度(DDDs)进行相关分析。结果:β-内酰胺类抗生素占抗生素总金额的比例逐年增长,2008年达62.48%;β-内酰胺/β-内酰胺酶抑制剂复合抗生素的总消耗金额比例则先增后减,2008年起呈明显下降趋势;两者金额比值由0.42降至0.13。2005年—2009年β-内酰胺/β-内酰胺酶抑制剂复合抗生素的品种数在β-内酰胺类抗生素及其复合制剂金额进入该年度前10位的药物中分别有4,3,3,2,1种;在DDDs进入该年度前10位分别有3,2,2,1,1种。结论:该中医院β-内酰胺/β-内酰胺酶抑制剂复合抗生素应用存在不合理现象,应加强抗生素的监管及用药前的药敏监测以减少抗生素不合理使用。
OBJECTIVE: To analyze the related factors of clinical use of β-lactam antibiotics and their combination preparations in a Chinese medicine hospital in Suzhou City, and to provide a reference for the rational use of such drugs in clinic. Methods: According to the retrospective analysis, the varieties, specifications, dosage forms, sales amount and total amount of β-lactam antibiotics and their combination preparations in this hospital from 2005 to 2009 were counted, and the order of the amount and frequency of DDDs related analysis. Results: The proportion of β-lactam antibiotics in the total amount of antibiotics increased year by year, reaching 62.48% in 2008; the proportion of total consumption of β-lactam / β-lactamase inhibitor antibiotics increased first and then decreased in 2008 The ratio between the two dropped from 0.42 to 0.13. Between 2005 and 2009, the number of β-lactam / β-lactamase inhibitor composite antibiotics in the β-lactam antibiotics and their combined preparations There were 4, 3, 3, 2, and 1 drugs in the top 10 of the year respectively; 3, 2, 2, 1, and 1 of the top 10 DDDs entered the year. Conclusion: The Chinese medicine hospital β-lactam / β-lactamase inhibitor composite antibiotics there is an unreasonable application of antibiotics should be strengthened supervision and drug susceptibility monitoring to reduce the irrational use of antibiotics.