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按口服葡萄糖耐量试验结果将研究对象分为糖耐量正常组 ( 75例 ) ,糖耐量低减组 ( 4 3例 )和2型糖尿病组 ( 5 4例 )。在这些不同糖耐量对象测定空腹血糖 ,真胰岛素 (TI) ,免疫反应性胰岛素 (IRI)和免疫反应性C肽 (IRC)并计算胰岛 β细胞功能指数HOMA β。结果显示TI能真实反应血中胰岛素水平 ;随着胰岛 β细胞功能减退 ,IRI与TI的相关性逐渐降低 ,IRC与TI在各不同糖耐量人群均有明显的相关性。提示在反映胰岛 β细胞功能方面IRC优于IRI。
According to oral glucose tolerance test results, subjects were divided into normal glucose tolerance group (75 cases), impaired glucose tolerance group (43 cases) and type 2 diabetes group (54 cases). Fasting plasma glucose, true insulin (TI), immunoreactive insulin (IRI) and immunoreactive C-peptide (IRC) were measured in these different glucose tolerance subjects and the islet beta cell function index HOMA beta was calculated. The results showed that TI could truly reflect the level of insulin in blood. With the decrease of pancreatic β-cell function, the correlation between IRI and TI gradually decreased. IRC and TI were significantly correlated with different glucose tolerance groups. It is suggested that IRC is superior to IRI in reflecting the function of pancreatic β-cells.