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目的:研究补肾壮阳类中药制剂及保健品中非法添加西地那非类似物——硫代西地那非的检测方法。方法:建立薄层色谱法、高效液相色谱法以及液相色谱-质谱联用技术对可能掺加硫代西地那非的中药制剂及保健品进行筛查检验。结果:薄层色谱、液相色谱结合紫外吸收光谱可给出筛查检测的初步结论,辅以液质联用技术提供的相对分子质量与结构信息,可对筛查结果作出准确判断。结论:本方法可检测中药制剂及保健品中违法添加的硫代西地那非。
OBJECTIVE: To study the detection method of the illicit addition of sildenafil in Chinese traditional medicine preparations and health products. Methods: The traditional Chinese medicine preparations and health products that could be mixed with thio-sildenafil were screened by TLC, HPLC and LC-MS. Results: The results of TLC and liquid chromatography coupled with ultraviolet absorption spectroscopy gave preliminary results of screening test, supplemented by relative molecular mass and structure information provided by liquid chromatography-mass spectrometry, which can make accurate judgment on screening results. Conclusion: This method can detect the illegal addition of thio-sildenafil in traditional Chinese medicine preparations and health products.