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目的探讨二磷酸果糖治疗新生儿窒息伴心肌损伤的临床疗效。方法选取玉林市玉州区妇幼保健院2015年11月—2016年8月收治的新生儿窒息伴心肌损伤患儿72例,按照随机数字表法分为对照组和试验组,各36例。对照组患儿采用常规治疗,试验组患儿在对照组基础上给予1,6二磷酸果糖治疗,两组患者均持续治疗2个疗程。比较两组患儿治疗前后心肌酶谱相关指标[肌酸激酶同工酶(CK-MB)、肌酸激酶(CK)、门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)]及临床疗效,观察两组患儿治疗期间不良反应发生情况。结果治疗前,两组患儿CK-MB、CK、AST、LDH比较,差异无统计学意义(P>0.05);治疗后,试验组患者CK-MB、CK、AST、LDH低于对照组(P<0.05)。试验组患儿治疗总有效率高于对照组(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用二磷酸果糖治疗新生儿窒息并心肌损伤的临床疗效确切,可有效改善患儿的心功能,且安全可靠。
Objective To investigate the clinical efficacy of fructose diphosphate in neonatal asphyxia with myocardial injury. Methods Totally 72 children with neonatal asphyxia and myocardial injury admitted to Yushu Maternal and Child Health Hospital of Yulin from November 2015 to August 2016 were divided into control group and experimental group according to random number table. The control group of children with conventional treatment, children in the experimental group were given fructose 1,6 diphosphate treatment on the basis of the control group, two groups of patients were treated for 2 courses. The levels of creatine kinase (CK-MB), creatine kinase (CK), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were compared between the two groups before and after treatment ] And clinical efficacy, observed two groups of children during treatment of adverse reactions occurred. Results Before treatment, the CK-MB, CK, AST and LDH in two groups had no significant difference (P> 0.05). After treatment, the CK-MB, CK, AST and LDH in the experimental group were lower than those in the control group P <0.05). The total effective rate of treatment group was higher than that of control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The fructose diphosphate treatment of neonatal asphyxia and myocardial injury clinical curative effect, can effectively improve children’s heart function, and safe and reliable.