目的:研究应用阿托伐他汀治疗早期病毒性心肌炎患者对T淋巴细胞亚群及血清炎症因子的影响。方法:将符合成人急性病毒性心肌炎患者60例随机分为治疗组(A组,30例)、对照组(B组,30例),两组患者均给予常规治疗。A组在常规治疗基础上给予阿托伐他汀,B组只给予常规治疗,服药持续时间为四周。结果:两组治疗前T淋巴细胞亚群比较无显著性差异,TNF-α及IL-10浓度比较亦无显著差异,两组治疗后比较,CD3+、CD4+、CD8+升高,CD4+/CD8+比值变小,TNF-α浓度降低,IL-10浓度升高,治疗前后有显著性差异(P<0.05)。治疗组与对照组治疗后比较,差异非常显著(P<0.01)。结论:阿托伐他汀能够下调炎症因子水平和上调抗炎因子水平从而改变炎症因子网络平衡,对急性病毒性心肌炎患者具有免疫调节作用。 AIM: To investigate the effect of atorvastatin on T lymphocyte subsets and serum inflammatory cytokines in patients with early viral myocarditis. Methods: 60 adult patients with acute viral myocarditis were randomly divided into treatment group (A group, 30 cases) and control group (B group, 30 cases). Both groups were given routine treatment. Group A received atorvastatin on the basis of routine treatment, Group B received only routine treatment, and the duration of medication was four weeks. Results: There was no significant difference in T lymphocyte subsets between the two groups before treatment, but the levels of TNF-α and IL-10 were not significantly different between the two groups. The levels of CD3 +, CD4 +, CD8 + and CD4 + / CD8 + Small, TNF-α concentration decreased, IL-10 concentration increased, before and after treatment were significantly different (P <0.05). The differences between the treatment group and the control group after treatment were significant (P <0.01). Conclusion: Atorvastatin can down-regulate the level of inflammatory cytokines and up-regulate the level of anti-inflammatory cytokines, thereby changing the balance of inflammatory cytokines and immunomodulatory effects in patients with acute viral myocarditis.