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为探讨接触4-氯邻甲苯胺及杀虫脒人群的膀胱癌发病率,进行了职业性队列研究。德国某化工厂自1965年12月起以4-氯邻甲苯胺为原料进行杀虫脒生产,由于当时生产条件差,常发生意外事故,导致生产工人接触较高浓度的化学物质。1976年该厂改善了工作条件,工人的接触水平降低,1986年停止生产杀虫脒。研究对象为该厂先后直接从事4-氯邻甲苯胺合成杀虫脒生产的男性工人,共49人。由工厂卫生所提供受试者的职业接触史和1990年底之前研究队列中的膀胱癌发病率与附近地区或国家按性别年龄别的膀胱癌预期发病率之比,计算出标化发病率(SIR),并测定了N-乙酰代表型。结果发现,研究队列在1982～1990年间共发生7例膀胱癌患者,其中包括4
To investigate the incidence of bladder cancer in patients exposed to 4-chloro-o-toluidine and chlordimeform, an occupational cohort study was conducted. Production of chlordimeform from 4-chloro-o-toluidine in a chemical plant in Germany since December 1965 resulted in frequent accidents due to poor production conditions at that time, resulting in exposure of production workers to higher concentrations of chemicals. In 1976, the factory improved working conditions, reduced workers’ exposure and stopped production of chlordimeform in 1986. The research object for the factory has been directly engaged in 4-chloro-o-toluidine maleicide production of chlordimeform, a total of 49 people. The standardized incidence (SIR) was calculated from the occupational exposure history of subjects provided by the factory health clinic and the ratio of the incidence of bladder cancer in the cohort before the end of 1990 to the expected incidence of bladder cancer by region or country by age of sex ), And the N-acetyl representative type was determined. The results found that the cohort of 7 patients with bladder cancer from 1982 to 1990 included 4