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目的探究贝那普利联合不同药物治疗慢性肾小球肾炎的临床效果。方法 80例慢性肾小球肾炎患者,按照随机序号法将患者分为对照组和观察组,各40例。对照组采用贝那普利联合肾炎康复片治疗,观察组采用贝那普利联合来氟米特治疗,观察并比较两组治疗效果。结果经治疗,观察组患者总有效率为90%,明显高于对照组的70%,差异具有统计学意义(P<0.05)。治疗前,两组患者血压、24 h尿蛋白定量、血肌酐等比较差异均无统计学意义(P>0.05);治疗后,观察组血压、24 h尿蛋白定量改善情况明显优于对照组,差异具有统计学意义(P<0.05)。治疗后两组血肌酐水平均无明显变化,比较差异无统计学意义(P>0.05)。结论贝那普利联合不同药物治疗慢性肾小球肾炎的效果不同,采用贝那普利联合来氟米特治疗能够较好的改善患者临床情况,同时提高治疗效果,因而值得在临床中借鉴使用。
Objective To investigate the clinical effect of benazepril combined with different drugs in the treatment of chronic glomerulonephritis. Methods Eighty patients with chronic glomerulonephritis were divided into control group and observation group according to random number method, 40 cases in each group. The control group was treated with benazepril combined with nephritis. The observation group was treated with benazepril combined with leflunomide. The therapeutic effect was observed and compared between the two groups. Results After treatment, the total effective rate in the observation group was 90%, which was significantly higher than that in the control group (70%), the difference was statistically significant (P <0.05). Before treatment, there was no significant difference in blood pressure, 24 h urinary protein and serum creatinine between the two groups (P> 0.05). After treatment, the improvement of 24 h urinary protein in the observation group was better than that in the control group, The difference was statistically significant (P <0.05). There was no significant difference in serum creatinine between the two groups after treatment (P> 0.05). Conclusion The combination of benazepril and different drugs has different effects on treating chronic glomerulonephritis. The combination of benazepril and leflunomide can improve the clinical condition and improve the therapeutic effect, so it is worth to be used in clinic .