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分泌型免疫球蛋白A(sIgA)主要存在于呼吸道、消化道、泌尿生殖道等粘膜表面的外分泌液中,是机体公共免疫系统(CMIS)的主要抗体,在局部免疫中起重要作用。近年来研究表明,免疫反应在一些常见的胆道系统疾病的发生和发展过程中具有十分重要的意义。本文通过放射免疫分析检测结石性慢性胆系炎症患者胆汁中slgA含量变化,探讨其发生机制及临床意义,现报道如下。 1 材料和方法 1.1 一般资料 全部对象均为择期手术患者,临床确诊并经手术证实为结石性慢性胆系炎症,既往无手术史,术前无黄疸和明显急性感染征象。单纯胆总管结石69例,胆总管伴胆囊结石12例,共81例。其中男23例,女58例,年龄27岁～73岁,平均49岁。所行术式为胆囊切除、胆总管切开取石T管引流术。
Secretory immunoglobulin A (sIgA) is mainly present in the exocrine fluid on the mucosal surfaces of the respiratory tract, digestive tract and urogenital tract. It is the major antibody to the public immune system (CMIS) of the body and plays an important role in local immunity. In recent years, studies have shown that the immune response in a number of common biliary disease occurrence and development process is of great significance. In this paper, radioimmunoassay in patients with calcified chronic biliary inflammation in patients with bile slgA content changes, to explore the mechanism and clinical significance, are reported below. 1 Materials and Methods 1.1 General Information All patients were elective surgery patients, clinically confirmed and confirmed by surgery for chronic biliary inflammation of stone, no previous history of surgery, no jaundice before surgery and significant signs of acute infection. 69 cases of simple common bile duct stones, common bile duct stones with gallbladder in 12 cases, a total of 81 cases. Including 23 males and 58 females, aged 27 years to 73 years, mean 49 years. The operation of cholecystectomy, common bile duct T-tube drainage.