论文部分内容阅读
目的探究在新生儿缺氧缺血性脑病(HIE)患者中予神经节苷脂钠(GM-1)联合高压氧(HBO)治疗的临床疗效。方法选取我科2009年7月-2011年2月90例HIE患儿临床资料行比较性分析,随机分为三组,治疗一组予普通式综合治疗法;治疗二组予普通治疗联合GM-1治疗;联合组予普通治疗联合GM-1及HBO共同治疗。结果三组病理在不同治疗方案治疗后,治疗一组治疗满意率(显著率+有效率)为73.33%;治疗二组为93.33%;联合组为100%。在三组治疗前后行NBNA评分结果比较中,治疗一组升高9.14±3.07分;治疗二组升高11.43±3.14分;联合组升高12.55±1.91分。P均<0.05,差异有统计学意义。结论 HIE在综合治疗后予HBO及GM-1治疗,可改善症状、缩短住院周期、减轻临床症状、提高治愈率、降低后遗症发生率。
Objective To investigate the clinical efficacy of ganglioside sodium (GM-1) combined with hyperbaric oxygen (HBO) in neonates with hypoxic-ischemic encephalopathy (HIE). Methods 90 cases of HIE in our department from July 2009 to February 2011 were selected and analyzed comparatively. The clinical data were divided into three groups at random. One group was treated by general therapy. The other two groups were treated with GM- 1 treatment; combined treatment group with general treatment GM-1 and HBO co-treatment. Results The pathology of three groups after treatment with different treatment regimens, the treatment satisfaction rate (significant rate + effective rate) was 73.33%; treatment group two was 93.33%; combination group was 100%. In the three groups before and after treatment NBNA score comparison, the treatment group increased 9.14 ± 3.07 points; treatment group two increased 11.43 ± 3.14 points; combined group increased 12.55 ± 1.91 points. P <0.05, the difference was statistically significant. Conclusions After HIE treatment, HBO and GM-1 can improve the symptoms, shorten the hospitalization period, reduce the clinical symptoms, improve the cure rate and reduce the incidence of sequelae.