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目的探讨亚临床甲状腺功能减退症(Subclinical Hypothyroidsm,SCH)对妊娠期母儿的影响。方法回顾性分析2013年1月~2014年10月在该院进行常规检查的妊娠合并甲减患者269例,根据是否愿意治疗分两组,经药物治疗组(159例),未经干预治疗观察组(110例),选取同期健康孕妇为对照组(200例)。比较3组孕妇妊娠期高血压疾病、流产、胎膜早破、早产、胎儿窘迫、产后出血患病率。结果观察组与其他两组比较,除妊娠期高血压疾病外,其余5方面患病率均升高,差异有统计学意义(P<0.05)。治疗组与对照组比较,6方面差异均无统计学意义(P>0.05);结论 SCH可导致妊娠期并发症及胎儿不良结局的发生,早期诊断及积极药物治疗可减少妊娠合并症发生,改善妊娠结局。
Objective To investigate the effect of subclinical hypothyroidism (SCH) on pregnant women and their children. Methods A retrospective analysis of 269 pregnant women with hypothyroidism undergoing routine examinations in our hospital from January 2013 to October 2014 was retrospectively analyzed. According to the willingness to treat in two groups, the patients in the medical treatment group (159 cases) were treated without intervention (N = 110). Healthy pregnant women of the same period were selected as the control group (n = 200). The incidence of gestational hypertension, miscarriage, premature rupture of membranes, premature labor, fetal distress and postpartum hemorrhage were compared between the three groups. Results Compared with the other two groups, the prevalence of other 5 aspects of pregnancy-induced hypertension was significantly higher in observation group (P <0.05). There was no significant difference between the treatment group and the control group (P> 0.05). CONCLUSIONS: SCH can lead to complications of pregnancy and fetal unhealthy outcome. Early diagnosis and active drug treatment can reduce the occurrence and improvement of pregnancy complications Pregnancy outcome.