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目的对严重急性呼吸综合征(SARS)康复期患者的血清免疫学指标进行前瞻性的临床研究。方法动态观察SARS患者出院后1、3和6个月时康复期特异性SARSIgG、T细胞亚群和血常规的变化。结果SARS患者血清特异性抗体可作为SARS的确诊依据,在SARS患者出院后6个月时间内,SARS患者血清IgG均呈较高水平,但随着时间的延长,IgG水平呈下降趋势。首次复查时,55.9%的患者T细胞亚群CD4+低于正常,31.2%的患者CD3+低于正常,14.0%的患者CD8+低于正常;第2次复查时绝大部分患者的T细胞亚群恢复至正常。首次复查时,仍有少数患者外周血白细胞异常,至第2次复查时均恢复至正常水平。结论部分SARS患者康复初期的T细胞亚群、白细胞计数均存在异常,至出院后6个月内绝大部分患者各项指标恢复正常;进一步观察SARS抗体水平变化规律,以及对相关异常指标进行跟踪观察研究是必要的。
Objective To carry out a prospective clinical study of serum immunological parameters in patients with convalescent acute respiratory syndrome (SARS). Methods The changes of convalescent SARSIgG, T cell subsets and blood routine in SARS patients at 1, 3 and 6 months after discharge were observed dynamically. Results Serum-specific antibodies in SARS patients could be used as the basis for the diagnosis of SARS. Serum IgG levels of patients with SARS were higher at 6 months after discharge from SARS patients, but IgG levels showed a decreasing trend with time. At the first review, 55.9% of patients had lower CD4 + T cell subsets than normal, 31.2% of patients had lower than normal CD3 +, and 14.0% of patients had lower than normal CD8 + T cell subsets at the second review To normal. The first review, there are still a few patients with peripheral white blood cell abnormalities, to the 2nd review were restored to normal levels. Conclusion Some SARS patients had abnormal T cell subsets and white blood cell counts during the initial rehabilitation, and most of the patients returned to normal within 6 months after discharge. The changes of SARS antibody levels and the follow-up of related abnormal indexes were also observed Observational studies are necessary.