对36例中晚期结直肠癌病人在术后早期行大剂量大容积5-FU腹腔化疗(IPC)。全组共接受109疗程545次IPC,完成1疗程36例,2疗程26例,3疗程18例,4疗程14例,5疗程8例,6疗程7例。化疗期间无明显血毒性反应,对肝肾功能无影响,未发生严重并发症,近期疗效满意。结果表明:IPC简便易行、安全,无严重毒副作用和并发症,是结直肠癌患者术后一种颇有前途的辅助化疗措施。 A large dose of large-volume 5-FU intraperitoneal chemotherapy (IPC) was performed early after surgery in 36 patients with advanced colorectal cancer. The entire group received 109 courses of 545 IPCs, completed 36 courses of 1 course of treatment, 26 courses of 2 courses, 3 courses of 18 cases, 4 courses of treatment in 14 cases, 5 courses of treatment in 8 cases, and 6 courses of treatment in 7 cases. There was no significant blood toxicity reaction during chemotherapy, no effect on liver and kidney function, no serious complications, and satisfactory curative effect in the near future. The results showed that: IPC is simple, safe, no serious side effects and complications, is a promising adjuvant chemotherapy for postoperative colorectal cancer patients.