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目的:荟萃分析地高辛对全因死亡率的影响。方法:收集Medline以及Cochrane数据文献,通过I~2统计量进行异质性检验,用随机效应模型分析地高辛对全因死亡的风险,得到合并效应指标风险比及其95%可信区间。结果:最终纳入文献10篇,总样本量24 865人,地高辛组的全因死亡率风险与对照组并无明显差异(HR1.04,95%CI 0.85~1.28,P=0.68)。结论:临床应用中地高辛并未显著升高全因死亡率。
OBJECTIVE: A meta-analysis of the effects of digoxin on all-cause mortality. Methods: The data of Medline and Cochrane were collected. The I ~ 2 statistics were used to test the heterogeneity. The random effect model was used to analyze the risk of all-cause death caused by digoxin. The risk ratio of combined effect index and its 95% confidence interval were obtained. Results: Ten articles were finally included in the literature, with a total sample size of 24,865 people. The all-cause mortality risk in the digoxin group was not significantly different from that in the control group (HR 1.04, 95% CI 0.85-1.28, P 0.68). Conclusion: Digoxin did not significantly increase all-cause mortality in clinical practice.