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目的:探讨食管癌放疗联合口服替加氟化疗增敏的疗效。方法:88例食管癌患者随机分组,44例同步放化疗,44例单纯放疗。化疗增敏方案:替加氟0.2tidpo;亚叶酸钙(同奥)10mgtidpo。放疗第一天始,同步进行。两组均给予6MV-X线,常规照射DT60-66Gy/30-33次/6-7周。结果:有效率分别为放化组100%,单放组72.75%(P<0.05);一年后复发率:放化组2.27%,单放组63.64%(P<0.01);两组毒副作用无明显差异(P>0.05)。结论:放疗联合口服替加氟治疗食管癌有效率高,复发率低,毒副作用小,病人易于接受。
Objective: To investigate the efficacy of radiosensitization of esophageal cancer combined with oral Tegafur chemotherapy. METHODS: Eighty-eight patients with esophageal cancer were randomly divided into groups, 44 patients received simultaneous radiotherapy and chemotherapy, and 44 patients received radiotherapy alone. Chemosensitization regimen: Tegafur 0.2 tidpo; leucovorin (alkali) 10 mg tidpo. The first day of radiotherapy began simultaneously. Both groups were given 6MV-X line, conventional irradiation DT60-66Gy / 30-33 times / 6-7 weeks. Results: The effective rates were 100% in radiochemotherapy group and 72.75% in radiotherapy group (P<0.05). The recurrence rate after one year was 2.27% in radiochemotherapy group and 63.64% in radiotherapy group (P<0.01); No significant difference (P>0.05). Conclusion: Radiotherapy combined with oral Tegafur is effective in the treatment of esophageal cancer, with low recurrence rate, small side effects and easy acceptance by patients.