【摘 要】
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Five pairs of optically pure meroterpenoid enantiomers (1a/1b-5a/5b) and two known compounds (6 and 7) were isolated from Rhododendron fastigiatum.Compounds 1a/1b-5a/5b were resolved from naturally scalemic mixtures by chiral HPLC.Their structures were el
【机 构】
：
School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203,
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Five pairs of optically pure meroterpenoid enantiomers (1a/1b-5a/5b) and two known compounds (6 and 7) were isolated from Rhododendron fastigiatum.Compounds 1a/1b-5a/5b were resolved from naturally scalemic mixtures by chiral HPLC.Their structures were elucidated by spectroscopic methods,X-ray crystallographic experiments,and ECD analyses.Compounds 1a/1b,2a/2b,3b,4a/4b,and 5a/5b were new meroterpenoids with different polycyclic systems.Two enantiomeric pairs (2a/2b and 3a/3b),6,and 7 exhibited inhibitory effects on protein tyrosine phosphatase 1B (PTP1B) in vitro.
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