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本文从预检温的筛选方式、筛选标准、稳定时间和不同基础体温的家兔对热原的敏感性等方面探讨了做好家兔热原实验值得注意的一些问题 ,并就美国药典和欧洲药典的要求进行了介绍和比较。建议对预检温筛选家兔采用至少与家兔热原实验一样的方式 ;为减少复试率和不合格率 ,应尽量不使用基础体温较低家兔进行实验。
This article from the pre-screening screening methods, screening criteria, stabilization time and different basal body temperature of the pyrogen sensitivity of the rabbit to do some experiments worthy of attention, and the United States Pharmacopoeia and Europe Pharmacopoeia requirements were introduced and compared. Proposed screening of pre-selected temperature rabbits using at least the same way as the rabbit pyrogen test; in order to reduce the retest rate and the failure rate, should try not to use the basal body temperature lower rabbits experiment.