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目的：探讨胃泌素在大肠癌发生发展中的作用及临床意义。材料和方法：随机选正常人２０例，结直肠炎症患者 １１例，息肉患者 ２３例，结直肠癌患者 ３２例，用放射免疫方法测定血清胃泌素水平，用免疫组织化学方法测定组织胃泌素、ＰＣＮＡ和ｐ５３蛋白表达水平。结果：结直肠炎、息肉及术前癌患者胃泌素水平升高（Ｐ＜０．０５），相互比较无显著差异（Ｐ＞ ０．０５）。胃泌素在息肉有 ２１．７４ ％表达，在癌组织有 ４０．６３％表达，分化较好的癌症胃泌素表达阳性率较高。胃泌求表达和Ｄｕｋｅｓ分期、ＰＣＮＡ，ｐ５３蛋白的表达无相关性。结沦：血清胃泌素水平测定不能作为筛查结直肠癌的标志。结直肠拈膜胃泌素的表达对结直肠癌发生发展有重要意义。胃泌素在结直肠癌的表达可以作为分化较好的标志。
Objective: To investigate the role of gastrin in the development of colorectal cancer and its clinical significance. MATERIALS AND METHODS: Totally 20 normal subjects, 11 patients with colorectal inflammation, 23 patients with polyps, 32 patients with colorectal cancer were recruited. Serum gastrin levels were measured by radioimmunoassay and gastrin secretion was measured by immunohistochemistry Superoxide dismutase, PCNA and p53 protein expression levels. Results: The levels of gastrin in patients with colitis, polyp and preoperative cancer were significantly increased (P <0.05), but no significant difference was found between them (P> 0.05). Gastrin in 21.74% of polyp expression, 40.63% in cancerous tissue expression, well differentiated cancer gastrin higher positive rate. Gastrin expression and Dukes staging, PCNA, p53 protein expression was not related. Conclusions: Serum gastrin levels can not be used as a marker of colorectal cancer screening. Colorectal mucosa gastrin expression of colorectal cancer occurrence and development of great significance. Gastrin in colorectal cancer can be used as a better indicator of differentiation.