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抗人肝癌铁蛋白IgG(AHFI)与柔红霉素(Dau)通过一中间载体葡聚糖T_(40)(Dex)连接成免疫偶联物AHFI-Dex-Dau。观察了其对皮下接种人肝癌细胞Bel-7402裸鼠的体内抑瘤作用。结果表明,AHFI-Dex-Dau可大大降低柔红霉素自身的毒性,可使荷瘤鼠存活期延长,并有明显的抑制肿瘤生长的作用。
Anti-human hepatoma ferritin IgG (AHFI) and daunorubicin (Dau) were linked by an intermediate carrier dextran T_(40) (Dex) into the immunoconjugate AHFI-Dex-Dau. The in vivo antitumor effect of subcutaneously inoculated hepatocellular carcinoma Bel-7402 nude mice was observed. The results showed that AHFI-Dex-Dau can greatly reduce the toxicity of daunorubicin itself, prolong the survival of tumor-bearing mice, and significantly inhibit the growth of tumors.