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目的探讨贝那普利对慢性充血性心力衰竭左心室功能、血管内皮舒张功能的影响。方法 2010年7月至2011年7月期间,我院诊治的98例慢性充血性心力衰竭患者,随机将其分为对照组和观察组,分别给予常规抗心衰治疗和联合贝那普利治疗,每组各49例,治疗6个月后,对两组的左心室功能、肱动脉内皮舒张功能,以及临床疗效,进行观察和比较。结果与对照组相比,观察组的左室舒张末期内径、收缩末期内径均明显降低,LVEF%明显升高,显著改善左室心功能,肱动脉血管内皮舒张功能得到了明显改善,总有效率明显提高,P<0.05,差异有统计学意义。结论对于慢性充血性心力衰竭患者,贝那普利能够明显改善心功能,疗效显著,显著提高患者的预后质量。
Objective To investigate the effects of benazepril on left ventricular function and vascular endothelial relaxation in patients with chronic congestive heart failure. Methods From July 2010 to July 2011, 98 patients with chronic congestive heart failure diagnosed and treated in our hospital were randomly divided into control group and observation group, and were given conventional anti-heart failure treatment and combined with benazepril treatment , 49 cases in each group. After 6 months of treatment, the left ventricular function, the diastolic function of brachial artery and the clinical curative effect were observed and compared. Results Compared with the control group, the left ventricular end-diastolic diameter and end-systolic diameter of the observation group were significantly decreased, the LVEF% was significantly increased, the left ventricular function was significantly improved, and the diastolic function of the brachial artery was significantly improved. The total effective rate Significantly increased, P <0.05, the difference was statistically significant. Conclusion In patients with chronic congestive heart failure, benazepril can significantly improve cardiac function, the curative effect is significant, and the prognosis quality of the patients is significantly improved.