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镉可影响小鼠腹腔巨噬细胞（Ｍ）对鸡红细胞的吞噬功能．为了探讨前列腺素Ｅ２（ＰＧＥ２）与这种吞噬功能的关系，经镉染毒后测定小鼠腹腔液ＰＧＥ２的水平．结果表明：投毒后２周，饮低镉组与对照组相比吞噬率、吞噬指数差异无显著性（Ｐ＞０．０５）；饮高镉组与对照组相比吞噬率、吞噬指数显著降低（Ｐ＜０．０１）；消炎痛加高镉组与单纯高镉组相比吞噬率显著增高（Ｐ＜０．０５）；加消炎痛各组ＰＧＥ２水平均低于非消炎痛组（Ｐ＜０．０１），ＰＧＥ２水平与巨噬细胞吞噬率呈负相关（Ｒ＝０．６６６３，Ｐ＜０．０１）．上述实验结果表明，高剂量镉对小鼠巨噬细胞吞噬功能具有显著抑制作用，ＰＧＥ２在镉对Ｍ吞噬功能毒作用中起重要作用．
Cadmium can affect mouse peritoneal macrophages (M) phagocytosis of chicken erythrocytes. In order to explore the relationship between prostaglandin E2 (PGE2) and phagocytosis, the level of PGE2 in peritoneal fluid of mice was determined after cadmium exposure. The results showed that there was no significant difference in the phagocytic rate and phagocytic index between the low cadmium group and the control group (P> 0.05) 2 weeks after drug administration. The phagocytic rate and phagocytic index of the high cadmium group were significantly higher than those of the control group (P <0.01). The phagocytic rate of indomethacin plus cadmium group was significantly higher than that of high cadmium group (P <0.05) <0.01). The level of PGE2 was negatively correlated with macrophage phagocytosis (R = 0.6663, P <0.01). The above experimental results show that high-dose cadmium has a significant inhibitory effect on macrophage phagocytosis in mice, and PGE2 plays an important role in the role of cadmium in phagocytosis of M phagocytes.