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重组人粒-巨噬细胞集落刺激因子(rhGM-CSF)在白血病及肿瘤病人大剂量放化疗白细胞减少性疾病的治疗中显示出了良好的前景。rhGM-CSF可明显改善屏蔽全骨盆后6.5Gy60Cor线照射犬的临床症状,加速外周血白细胞的恢复,提高白细胞的最低值,缩短白细胞减少的持续时间。可明显增加照射犬骨髓有核细胞数及骨髓细胞数,促进骨髓CFU-GM的增殖,提高骨髓细胞的粒/红比值。可应用于事故性骨髓型急性放射病病人的临床治疗。
Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) has shown promising prospects in the treatment of leukemia and cancer patients with high-dose radiotherapy and chemotherapy leukemia. rhGM-CSF can significantly improve the clinical symptoms of dogs exposed to 6.5Gy60Cor line after shielding the whole pelvis, accelerate the recovery of peripheral leukocytes, raise the minimum of white blood cells and shorten the duration of leukopenia. Can significantly increase the number of irradiated canine bone marrow cells and bone marrow cells, promote bone marrow CFU-GM proliferation and increase the bone marrow cells of the grain / red ratio. It can be used in the clinical treatment of patients with accidental bone marrow acute radiation sickness.