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目的 :探讨半夏泻心汤及其拆方对应激性胃溃疡的作用机理。方法 :采用水浸 束缚应激造成大鼠急性胃溃疡模型 ,观察半夏泻心汤及其拆方各组对其治疗作用及其对P物质(SP)的影响 ,为半夏泻心汤配伍规律的探讨提供科学实验研究的参照。结果 :与正常组相比 ,模型组SP的表达明显增强。半夏泻心汤全方及各拆方组可以通过下调SP的表达体现出治疗作用 ,其中甘补药组下调作用最为明显 ,苦降药组其次 ,辛开药组作用最弱 ,两两配合后的作用表现出复杂性 ,虽然下调作用减弱 ,但综合治疗作用增强。
Objective :To explore the mechanism of action of Banxia Xiexin Decoction and its decomposed recipe on stress gastric ulcer. Methods: Acute gastric ulcer model induced by water-immersion restraint stress was used to observe the effect of Banxia Xiexin Decoction and its disassembled groups on its therapeutic effect and Substance P (SP). It was used in combination with Banxia Xiexin Decoction. The discussion of laws provides a reference for scientific experimental research. Results: Compared with the normal group, the expression of SP in the model group was significantly increased. Banxia Xiexin Decoction and its decomposing prescriptions group can show therapeutic effect by down-regulating the expression of SP, among which Ganzhi tonic group has the most obvious down-regulation effect, followed by bitter drop-drug group, Xinqin drug group has the weakest effect, and the effect of combination of two and two. Complexity appeared, although the down-regulation weakened, but the comprehensive treatment effect was enhanced.