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目的 :评价舍曲林治疗阿片类药物依赖者脱毒后抑郁症的临床疗效及副作用。方法 :将临床已脱毒的阿片类药物依赖者存在情感障碍符合 CCMD— 2—R关于抑郁症或抑郁性神经症诊断标准的 6 2例患者 ,用贯序法随机分为舍曲林组和丙咪嗪组 ,对照治疗观察 8周 ,采用 Hamilton抑郁量表 (HRSD)、临床疗效总评量表 (CGI)、治疗药物副作用量表 (TESS)评定疗效和副作用。结果 :两组病人在治疗结束时临床疗效、HRSD减分率均无显著差异 ,舍曲林副作用的发生率及严重程度较丙咪嗪显著的少而轻。结论 :舍曲林可以安全有效的治疗阿片类药物依赖者脱毒后抑郁症
Objective: To evaluate the clinical efficacy and side effects of sertraline in treating post-desensitization depression in opiate dependent patients. Methods: Sixty two patients with clinically desensitized opioid dependence who met CCMD-2-R criteria for diagnosis of depression or depressive neurosis were randomly divided into sertraline group Imipramine group, control treatment for 8 weeks, using Hamilton depression scale (HRSD), clinical efficacy of the total rating scale (CGI), therapeutic drug side effects scale (TESS) evaluation of efficacy and side effects. Results: The clinical curative effect and HRSD reduction rate of two groups of patients had no significant difference at the end of treatment. The incidence and severity of sertraline side effects were significantly less and less than that of imipramine. Conclusion: Sertraline can be a safe and effective treatment for post-detoxification depression in opiate dependent patients