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目的:本研究旨在探讨TNF-α和IL-8在变应性鼻炎发病中的作用。方法:对102例季节性或常年性变应性鼻炎患者的血清TNF-α和IL-8浓度进行测定,并比较脱敏治疗前后浓度的变化。结果:观察组TNF-α和IL-8治疗前明显增加,和对照组比较差异有统计学意义,观察组脱敏治疗后TNF-α和IL-8血清浓度明显降低,与治疗前比较差异有统计学意义。结论:在变应性鼻炎的发病中,TNF-α和IL-8发挥了重要的作用。
Objective: This study was designed to investigate the role of TNF-α and IL-8 in the pathogenesis of allergic rhinitis. Methods: The serum levels of TNF-α and IL-8 in 102 patients with seasonal or perennial allergic rhinitis were measured and compared before and after desensitization treatment. Results: The levels of TNF-α and IL-8 in the observation group were significantly increased before treatment, which were significantly different from those in the control group. The concentrations of TNF-α and IL-8 in the observation group were significantly decreased after desensitization treatment, Statistical significance. Conclusion: In the pathogenesis of allergic rhinitis, TNF-α and IL-8 play an important role.