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目的探讨阿托伐他汀钙治疗肾病综合征高脂血症的临床治疗效果。方法本研究选取肾病综合征高脂血症患者60例为研究对象,随机分为观察组(阿托伐他汀钙联合标准激素治疗组)30例和对照组(标准激素治疗组)30例,统计、观察比较两组患者的临床疗效情况。结果观察组患者在血脂下降方面明显优于对照组,差异有统计学意义(P<0.05);两组间24 h尿蛋白定量,肝、肾功能比较差异无统计学意义(P>0.05)。结论阿托伐他汀口服给药用于治疗肾病综合征高脂血症具有起效快、不良反应安全性好的特点,值得在临床推广使用。
Objective To investigate the clinical effect of atorvastatin calcium in treating hyperlipemia with nephrotic syndrome. Methods Sixty patients with nephrotic syndrome and hyperlipidemia were randomly divided into observation group (atorvastatin calcium combined with standard hormone therapy group) and control group (standard hormone therapy group) , Observed and compared the clinical efficacy of two groups of patients. Results The observation group was significantly better than the control group in the decline of blood lipids, the difference was statistically significant (P <0.05). There was no significant difference in 24 h urine protein, liver and kidney function between the two groups (P> 0.05). Conclusion Oral administration of atorvastatin for the treatment of nephrotic syndrome with rapid onset of hyperlipidemia, adverse reactions and good safety characteristics, it is worth promoting in clinical use.