人们对好几种动物的自然性铜缺乏或实验性铜缺乏产生的病理变化进行了研究。虽然多种实验动物曾广泛地被用来评价铜的生理意义,但只报导实验小鼠有由于铜代谢导致的遗传性缺陷,呈现神经系统病变,免疫反应抑制,及可以增补铜来防止肌贫血的发生。小鼠可为研究铜缺乏在儿科上的问题提供有效的动物模型。本文描述了小鼠实验性铜缺乏的病理学。材料和方法实验用食物是一种含18％蛋白质的脱脂 Studies have been conducted on the pathological changes caused by copper deficiency in nature or experimental copper deficiency in several animals. Although a large number of experimental animals have been widely used to evaluate the physiological significance of copper, only experimental mice have been reported to have inherited defects due to copper metabolism, neurological changes, suppression of immune responses, and copper supplementation to prevent anemia happened. Mice can provide an effective animal model for the study of pediatric deficiencies in copper deficiency. This article describes the pathology of experimental copper deficiency in mice. Materials and Methods The experimental diet consisted of a degreasing of 18% protein