论文部分内容阅读
本文应用中性红摄取法对柯萨奇B组病毒的6个血清型(CoxB_(1～6))在细胞培养上对自然人白细胞干扰素(nIFN～α)的敏感性进行了比较研究。表明:CoxB_(1～6)对nIFN—α的敏感性有显著差异(P<0.01),其中CoxB_4最为敏感,CoxB_3最不敏感。本文同时比较了3型腺病毒(Ad_3)和7型腺病毒(Ad_7)的2个基因组型Ad_(7b)和Ad_(7b)对nIFN—α的敏感性,结果表明:Ad_3较Ad_(7b)和Ad_(7d)敏感(P<0.01和P<0.05),并且Ad_(7b)和Ad_(7d)对nIFN—α的敏感性也不同(P<0.05)。本文为干扰素的临床应用提供了实验依据。
In this paper, we compared the sensitivity of CoxB_ (1-6) to natural human leukocyte interferon (nIFN ~ α) in Coxsackie B virus by neutral red ingestion method. The results showed that the sensitivity of CoxB_ (1-6) to nIFN-αwas significantly different (P <0.01), of which CoxB_4 was the most sensitive and CoxB_3 the least sensitive. In this study, the sensitivity of Ad-7 and Ad-7 genotypes to Ad-7 and Ad-7 to nIFN-α was also compared. The results showed that compared with Ad_3 and Ad_7, And Ad_ (7d) (P <0.01 and P <0.05), and the sensitivity of Ad_ (7b) and Ad_ (7d) to nIFN-α was also different (P <0.05). This article provides the experimental basis for the clinical application of interferon.