缺血缺氧性损害一直是妨碍严重烧伤治愈率进一步提高的关键问题,尽管伤后及时给予复苏,但缺血缺氧性损害仍难以避免。究其原因,一是烧伤后血液灌流不足,除了毛细血管通透性增加使有效血容量减少外,是否还有别的启动因素参与尚不清楚；二是细胞病理性缺氧的机制未明了,因而临床上缺乏有针对性的措施。近年来,在观察并证实严重烧伤后早期存在心肌损害的基础上,人们针对其细胞分子机制与防治策略进行了深入的研究。 Hypoxic-ischemic damage has been a key problem that hinders the further improvement of the cure rate of severe burn. Despite the timely recovery from injury, the hypoxic-ischemic damage is still unavoidable. The reason, one is the lack of blood perfusion after burn, in addition to increased capillary permeability to reduce effective blood volume, whether there are other factors involved in the startup is unclear; second is the mechanism of cytopathogenic hypoxia is not clear, Therefore, the clinical lack of targeted measures. In recent years, on the basis of observing and confirming the early myocardial damage after severe burns, people have conducted in-depth research on the molecular mechanism and prevention and cure strategies of the cells.