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目的 :探讨细胞凋亡与膀胱癌临床生物学行为的关系。方法 :采用末端脱氧核苷酸转移酶介导缺口末端标记法 (TUNEL)进行膀胱癌细胞凋亡的检测。结果 :49例膀胱癌标本共有 43例 (87 76 % )发生细胞凋亡 ,细胞凋亡指数为 (45 6 6± 12 49) % ,细胞凋亡指数大小与病人年龄、性别、肿瘤大小、数目无关 (P >0 0 5 ) ,与肿瘤分级、分期呈负相关 (P <0 0 1) ,即肿瘤“瘤级”和“瘤期”越高 ,则细胞凋亡越少 ,易复发肿瘤其细胞凋亡指数明显小于不复发肿瘤 (P <0 0 5 )。结论 :膀胱癌细胞凋亡与肿瘤分级、分期及预后有关。膀胱癌细胞凋亡减少提示肿瘤分化差、易浸润 ,且病人预后较差。
Objective: To investigate the relationship between apoptosis and clinical biological behavior of bladder cancer. Methods: Detection of apoptosis of bladder cancer cells by terminal deoxynucleotidyl transferase mediated nick end labeling (TUNEL). Results: A total of 43 cases (87 76%) of 49 cases of bladder cancer showed apoptotic index (456 ± 1249)%. The index of apoptosis was correlated with the age, sex, tumor size and number (P> 0.05), which was negatively correlated with tumor grade and stage (P <0.01), that is, the higher the “tumor grade” and “tumor stage” The apoptotic index was significantly lower than that without recurrence (P <0.05). Conclusion: The apoptosis of bladder cancer is related to tumor grade, stage and prognosis. Apoptosis of bladder cancer cells suggest poor differentiation, easy invasion, and the patient’s prognosis is poor.