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应用ＰＣＲ对３３例小儿急性淋巴细胞白血病（ＡＬＬ）进行免疫球蛋白重链（ＩｇＨ）及Ｔ细胞受体γ（ＴＣＲγ）基因重排研究，以探讨该２种重排在小儿ＡＬＬ的发生规律及与免疫分型的关系。结果显示：ＩｇＨ阳性１９例（５７．６％），ＴＣＲγ阳性１０例（３０．３％）。有７例ＩｇＨ及ＴＣＲγ均呈阳性，其中５例来自Ｂ系或Ｔ系分化早期的淋巴细胞白血病，提示在儿童初发淋巴细胞白血病中，ＩｇＨ基因重排的发生率明显高于ＴＣＲγ基因重排，且在免疫表型为分化早期的Ｔ或Ｂ淋巴细胞白血病中，并存上述２种基因重排的可能性很大。
33 cases of pediatric acute lymphoblastic leukemia (ALL) were immunoglobulin heavy chain (IgH) and T cell receptor γ (TCRγ) gene rearrangement study by PCR to explore the law of the two rearrangements in children with ALL and Relationship with immunotyping. The results showed that: IgH positive in 19 cases (57.6%), TCRγ-positive in 10 cases (30.3%). 7 cases of IgH and TCRγ were positive, of which 5 cases from the B line or T line differentiation of early lymphocytic leukemia, suggesting that in children with primary lymphoblastic leukemia, IgH gene rearrangement was significantly higher than the incidence of TCRγ gene rearrangement , And in immunophenotyping as early stage of differentiation of T or B lymphoblastic leukemia, the coexistence of these two gene rearrangement is very likely.