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利用免疫组织化学方法，对６４例，年龄在２２～７６岁之间患者的宫颈脱落细胞中Ｐ５３的表达进行检测，结果发现：Ｉ级细胞２８例，Ⅱ细胞３３例中Ｐ５３表达均为阴性，Ⅱ～Ⅲ级细胞３例中２例Ｐ５３表达阳性（６６．６％）；Ｐ５３表达阳性与宫颈病变患者年龄无关。结果提示：利用免疫组织化学方法，检测宫颈脱落细胞中Ｐ５３表达，对宫颈癌的早期诊断有一定的意义。
Using immunohistochemistry to detect the expression of P53 in cervical exfoliated cells in 64 patients between the ages of 22 and 76 years. The results showed that the expression of P53 was negative in 28 cases of grade I and 33 cases of Ⅱ, The positive expression of P53 was found in 2 of 3 cases of grade Ⅱ ~ Ⅲ cells (P <0.05). The positive expression of P53 was not associated with the age of cervical lesions. The results suggest that using immunohistochemistry to detect the expression of P53 in cervical exfoliated cells has certain significance for the early diagnosis of cervical cancer.