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目的通过比较非瓣膜性心房颤动(NVAF)及瓣膜性心房颤动(VAF)所致缺血性脑卒中患者中国缺血性卒中亚型(CISS)分型,探讨NVAF缺血性脑卒中可能的发病机制。方法收集129例NVAF及VAF缺血性脑卒中患者的临床资料,对所有患者进行CISS分型,比较NVAF组(96例)及VAF组(33例)年龄、相关危险因素及CISS分型情况。结果两组患者年龄、高血压、糖尿病等因素方面比较差异具有统计学意义(P<0.05),NVAF组主要表现为复合颅内外大动脉粥样硬化的卒中(包括CS+LAA型及CS+LAA+PAD型)占60.4%,两组患者卒中CISS分型比较差异具有统计学意义(P<0.05)。结论颅内动脉粥样硬化与NVAF缺血性脑卒中密切相关,可能是NVAF患者发生缺血性脑卒中的一个重要机制。
Objective To compare the possible types of ischemic stroke subtypes (CISS) in patients with ischemic stroke caused by non-valvular atrial fibrillation (NVAF) and valvular atrial fibrillation (VAF) and explore the possible pathogenesis of NVAF ischemic stroke mechanism. Methods The clinical data of 129 NVAF and VAF ischemic stroke patients were collected. CISS was performed on all patients. The age, related risk factors and CISS classification of NVAF group (n = 96) and VAF group (33 patients) were compared. Results There were significant differences between the two groups in age, hypertension, diabetes and other factors (P <0.05). NVAF mainly manifested as complex intracranial and extra-arterial atherosclerosis (including CS + LAA type and CS + LAA + PAD type) accounted for 60.4%, two groups of patients with stroke SISS classification difference was statistically significant (P <0.05). Conclusion Intracranial atherosclerosis is closely related to NVAF ischemic stroke and may be an important mechanism of ischemic stroke in patients with NVAF.