以缬氨酸氧肟酸为筛选剂 ,对替考拉宁产生菌替考游动放线菌 (Actinoplanes teichomyceticus)进行了推理选育 ,获得了发酵总效价和 TA2 - 2 组分含量均较出发菌株高的缬氨酸氧肟酸抗性变株 98- 1- 2 2 7。传代试验表明菌株 98- 1- 2 2 7的遗传特性较稳定。对菌株 98- 1- 2 2 7和出发菌株 97- 5 - 74的形态、生代特性进行了比较。 With valine hydroxamate as the screening agent, Actinoplanes teichomyceticus was selected by reasoning and breeding, and the total fermentation titers and TA2 - 2 contents were obtained. The starting strain of valine hydroxamic acid resistant mutant 98-1-227. Passage experiments showed that the genetic characteristics of strain 98-1-227 were more stable. Morphological and biotic characteristics of strain 98-1-227 and strain 97-5-7 were compared.