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通过应用识别大鼠阿片μ-受体（MOR）C末端30个氨基酸残基特异性位点的豚鼠抗体，本文对日本猴颈、胸、腰、骶段脊髓和背根节内MOR-样免疫反应物质的分布形式和特点进行了免疫组织化学研究。结果如下：强染色MOR－Li密集分布于脊髓吻尾全长的背角浅层，主要以Rexed第二层内侧部为主。在脊髓背角深层和中央导水管周围区域内也可见中到低等数量的MOR-Li标记。在脊髓背角浅层，MOR-Li广泛分布于Ⅰ、Ⅱ层内神经毯和神经元突起，但似乎只分布于第Ⅱ层神经元胞体。背角深层（Ⅳ－Ⅵ层）有些神经元的胞体和树突也有较强的MOR－Li染色。MOR－Li在背根入髓区和Lissauer’s氏束中分布密集且染色强。在后根节，MOR－Li主要分布于中、小细胞，其中MOR－Li阳性小细胞约占65.71％（1018／1562），直径平均为29.50±0．11μm（17．31～34．88μm），中等细胞约占34．19％（534／1562），直径平均为39．04±0．14μm（24.01～49．86μm），而MOR－Li阳性的大细胞只占0．64％（10／1562），直径平均为59.00±2.35μm（51．09～71．39μm）。本结果揭示猴脊髓内阿片肽主要通过突触前和突触后两种方式发挥镇痛作用，除此之外，还可能通过作用于外周伤害性感受器部位的MOR发挥镇痛作用。
By applying the guinea pig antibody that recognizes the 30 amino acid residue-specific site of μ-receptor (MOR) in rat ophthalmology, MOR-like immunity in the cervical, thoracic, lumbar, and sacral spinal cords of the Japanese monkey and in the dorsal root ganglia The distribution and characteristics of reactive substances were studied by immunohistochemistry. The results are as follows: Strongly stained MOR-Li is densely distributed in the superficial dorsal horn of the entire length of the tail of the spinal cord, mainly in the medial part of the second layer of Rexed. Middle-to-low MOR-Li labeling was also seen in the deep spinal dorsal horn and in the area around the central aqueduct. In the superficial spinal dorsal horn, MOR-Li is widely distributed in neuronal blanket and neurite outgrowths in layers I and II, but appears to be distributed only in the neuronal soma of layer II. Deep dorsal horn (Ⅳ-Ⅵ layer) Some neurons cell body and dendrites also have strong MOR-Li staining. Mor-Li is densely distributed and strongly stained in the dorsal root marrow and Lissauer’s sperm bundles. MOR-Li mainly distributed in small and medium-sized cells in MOR. Among them, MOR-Li positive small cells accounted for 65.71% (1018/1562) and average diameter was 29.50 ± 0.11μm (17.31 ~ 34.88μm) , Moderate cells accounted for 34.19% (534/1562), average diameter was 39.04 ± 0.14μm (24.01 ~ 49.86μm), while MOR-Li positive macrophages accounted for only 0.64% (10 / 1562) with an average diameter of 59.00 ± 2.35 μm (51.09 to 71.39 μm). The results revealed that opioid peptide in the spinal cord of the monkey exerts analgesic action mainly through presynaptic and postsynaptic actions. In addition, it may exert analgesic action through MOR acting on the peripheral nociceptors.