Noncanonical NF-κB Signaling Pathway in Liver Diseases

来源 :临床与转化肝病杂志(英文版) | 被引量 : 0次 | 上传用户:vito23
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
The noncanonical NF-κB signaling pathway is an important branch of NF-κB signaling. It is involved in regulating mul-tiple important biological processes, including inflammation and host immune response. A central adaptor protein of the noncanonical NF-κB pathway is NF-κB-inducing kinase (NIK), which activates the downstream kinase IKKα to pro-cess p100 to p52, thereby forming the RelB/p52 heterodi-mer to initiate the expression of target genes. Currently, many specific inhibitors and monoclonal antibodies target-ing or triggering this pathway are being developed and tested for various diseases, including cancers, autoimmune diseases, and virus infection. Given that aberrant activation of the noncanonical NF-κB pathway is frequently observed in various liver diseases, targeting this pathway may be a promising therapeutic strategy to alleviate liver inflamma-tion. Moreover, activation of this pathway may contribute to the antiviral immune response and promote the clear-ance of persistent hepatotropic virus infection. Here, we review the role of the noncanonical NF-κB pathway in the occurrence and development of different liver diseases, and discuss the potency and application of modulating the noncanonical NF-κB pathway for treatment of these liver diseases.
其他文献
目的:分析老年前列腺增生用癃清片配合坦索罗辛治疗效果.方法:取78例本院(2018年3月至2020年4月)收治的年前列腺增生患者进行研究,回顾病例,以不同疗法作为分组依据,分为对照