论文部分内容阅读
目的:探讨孕期注射乙肝免疫球蛋白(hepatitis B immunoglobulin,HBIG)对HBV母婴传播的影响及婴儿对乙肝疫苗免疫应答情况。方法:以HBsAg阳性孕妇及其新生儿为研究对象,孕期注射乙肝免疫球蛋白的孕妇300例及新生儿为实验组,未使用者80例为对照组,比较两组新生儿宫内感染率及出生时和7个月抗体产生情况。结果:孕期注射HBIG组与未注射组新生儿宫内感染率分别为5.33%(16/300)和1.25%(1/80),差异无统计学意义(χ2=2.464,P>0.05);孕期注射HBIG组与未注射组新生儿出生时anti-HBs阳性率分别为10.33%(31/300)和1.25%(1/80),差异有统计学意义(χ2=6.757,P<0.05),7个月龄anti-HBs产生率为96.12%(124/129)和95.35%(41/43),差异无统计学意义(χ2=0.049,P>0.05);出生时anti-HBs阳性的新生儿25例,7个月复查均产生anti-HBs,而出生时anti-HBs阴性或弱阳性的147例婴儿,7个月复查有7例婴儿anti-HBs仍为阴性或弱阳性,但差异无统计学意义(χ2=0.321,P>0.05)。结论:孕期注射HBIG不能降低HBV宫内感染率,可提高新生儿出生时anti-HBs阳性率,但对7个月anti-HBs产生率无影响。
Objective: To investigate the effect of hepatitis B immunoglobulin (HBIG) during pregnancy on the transmission of HBV in mother and infant and the immune response to hepatitis B vaccine in infants. Methods: The HBsAg-positive pregnant women and their newborns were selected as the research objects. 300 pregnant women with HBsAg during pregnancy and neonates as experimental group and 80 non-users as control group were enrolled in this study. Antibody production at birth and at 7 months. Results: The intrauterine infection rates of newborns during HBIG group and non-injection group during pregnancy were 5.33% (16/300) and 1.25% (1/80), respectively, with no significant difference (χ2 = 2.464, P> 0.05) The positive rates of anti-HBs at birth in HBIG group and non-injected group were 10.33% (31/300) and 1.25% (1/80), respectively, with statistical significance (χ2 = 6.757, P <0.05) The positive rates of anti-HBs in one month were 96.12% (124/129) and 95.35% (41/43) respectively, with no significant difference (χ2 = 0.049, P> 0.05) For example, anti-HBs were found in all 7-month follow-up and in 147 infants with negative or weak anti-HBs at birth, 7 infantile anti-HBs were still negative or weakly positive at 7 months, but the difference was not statistically significant Significance (χ2 = 0.321, P> 0.05). Conclusion: Intrauterine injection of HBIG during pregnancy can not decrease the intrauterine infection rate of HBV, which can increase the positive rate of anti-HBs at birth, but has no effect on the anti-HBs production rate at 7 months.