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目前尚无可供人类嗜肝病毒研究应用细胞系的情况下,通过向小鼠肝内移植人类肝细胞为研究人类肝脏疾病和嗜肝病毒提供了一个极好的体内模型。 近来,通过移植啮齿类动物土拨鼠的肝细胞至尿激酶型胞浆素原激活因子(uPA)转基因小鼠的肝内建立了一种动物模型。此uPA转基因小鼠同时敲除重
There is currently no available cell line for human hepadnavirus studies and an excellent in vivo model for the study of human liver disease and hepadnavirus is provided by intrahepatic transplantation of human hepatocytes into mice. Recently, an animal model has been established by transplanting liver cells from rodent marmots into the liver of urokinase-type plasminogen activator (uPA) transgenic mice. This uPA transgenic mice knocked off heavy at the same time