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本文进行了用以丹参为主的中药复方(861)治疗肝纤维化的实验与临床初步研究。第一部分以大鼠白蛋白免疫损伤性肝纤维化模型观察中药复方丹参提取液及颗粒冲剂的抗肝纤维化作用。以正常大鼠、单纯白蛋白模型、秋水仙碱治疗为对照组,结果表明复方丹参提取液有抗纤维化作用(P<0.05～0.01),效果与秋水仙碱相似(P<0.05)。又证明861提取液与颗粒冲剂疗效相仿(P<0.05),表明临床上可用颗粒冲剂代替提取液。免疫组化证明复方中药
In this paper, an experimental and clinical preliminary study of the treatment of liver fibrosis with traditional Chinese medicine compound (861) based on Salvia miltiorrhiza. In the first part, we observed the anti-hepatic fibrosis of Salvia miltiorrhiza extract and granule in rats with albumin immunostative liver fibrosis model. The normal rats, pure albumin model, colchicine treatment as control group, the results showed that compound Salvia extract has anti-fibrosis (P <0.05 ~ 0.01), the effect is similar to colchicine (P <0.05). Also proved 861 extract and granules granules similar efficacy (P <0.05), indicating that clinically available granules granules instead of extract. Immunohistochemistry compound Chinese medicine