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目的 探讨白细胞介素 8(IL 8)及皮质醇含量的变化及其与特发性早产的关系。方法 采用酶联免疫吸附 (ELISA)法 ,检测 35例特发性早产孕妇 (早产组 )及 17例同期正常孕妇 (对照组 )血清和尿液中IL 8含量 ,并用放射免疫法检测血清中皮质醇含量。结果 早产组孕妇血清、尿液中IL 8含量分别为 (0 2 6± 0 13) μg/L、(0 16± 0 15 )× 10 -2 g/mol肌酐 ,明显高于对照组的 (0 16± 0 0 8)μg/L、(0 0 4± 0 0 2 )× 10 -2 g/mol肌酐 (P <0 0 5 ,P <0 0 1) ;早产组孕妇血清皮质醇含量为 (76 5 83±40 8 5 5 ) μg/L ,明显高于对照组的 (5 12 41± 142 6 5 ) μg/L(P <0 0 1) ;早产组血清中IL 8与皮质醇含量呈正相关关系 (r =0 44 8,P <0 0 5 )。结论 IL 8和皮质醇含量的变化在早产的发病中起着重要作用
Objective To investigate the changes of interleukin 8 (IL 8) and cortisol and their relationship with idiopathic preterm labor. Methods Serum and urine IL-8 levels were measured by enzyme-linked immunosorbent assay (ELISA) in 35 pregnant women with idiopathic preterm birth (preterm birth) and 17 normal pregnant women (control group) at the same period. Radioimmunoassay was used to detect serum cortical Alcohol content. Results The level of IL 8 in serum and urine of preterm labor group was (0 26 ± 0 13) μg / L and (0 16 ± 0 15) × 10 -2 g / mol creatinine respectively, which was significantly higher than that of the control group 16 ± 0 0 8) μg / L and (0 0 4 ± 0 0 2) × 10 -2 g / mol creatinine (P 0 05, P 0 01). The serum cortisol level in preterm labor group was ( 76 5 83 ± 40 8 5 5 μg / L) was significantly higher than that of the control group (5 12 41 ± 142 6 5) μg / L (P 0 01). The levels of IL 8 and cortisol in preterm labor group were positive Correlation (r = 0 44 8, P <0 0 5). Conclusion The changes of IL 8 and cortisol content play an important role in the pathogenesis of preterm labor