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目的探讨妊娠期糖尿病(GDM)患者血清维生素D水平与胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)、脂联素(APN)、视黄醇结合蛋白4(RBP4)及血糖水平的关系。方法选取2015年1月-2016年6月在广汉市人民医院确诊的120例GDM患者为GDM组;另选取同期正常妊娠妇女60例为正常组,检测两组相关生化指标并进行相关性分析。结果 GDM组血清25-(OH)D、HOMA-β、APN低于正常组(P<0.05),GDM组的HOMA-IR、RBP4、空腹血糖(FPG)、餐后2 h血糖(2h PG)高于正常组(P<0.05);GDM组血清25-(OH)D与HOMA-β、APN呈正相关关系(P<0.05),GDM组的25-(OH)D与HOMA-IR、RBP4、FPG、2h PG呈负相关关系(P<0.05)。结论 GDM患者存在维生素D不足,并且与患者的血糖及胰岛素抵抗、胰岛细胞功能具有一定的关系。
Objective To investigate the relationship between the levels of serum vitamin D and the levels of insulin resistance index (HOMA-IR), islet beta cell function index (HOMA-β), adiponectin (APN), retinol binding protein 4 (RBP4) in patients with gestational diabetes mellitus (GDM) And blood glucose levels. Methods A total of 120 GDM patients diagnosed in Guanghan People’s Hospital from January 2015 to June 2016 were selected as GDM group. Another 60 normal pregnant women were selected as normal group. The related biochemical indexes were detected and analyzed. Results Serum levels of 25- (OH) D, HOMA-β and APN in GDM group were lower than those in normal group (P <0.05). HOMA-IR, RBP4, FPG and 2h PG in GDM group were lower than those in normal group (P <0.05). There was a positive correlation between 25- (OH) D and HOMA-β, APN in GDM group (P <0.05) FPG, 2h PG was negatively correlated (P <0.05). Conclusion There is deficiency of vitamin D in patients with GDM, and it has certain relation with blood glucose, insulin resistance and islet cell function.