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二性霉素 B 是杀真菌的多烯抗生素,近来临床报告它能引起血小板减少。其原因归于它对骨髓的抑制作用。作者对4例接受二性霉素 B 治疗的急性白血病患者进行了研究。3例急性粒细胞白血病,1例早幼粒白血病,均接受抗白血病化疗。规定病人在用抗菌素72小时后仍然发热者即开始用二性霉素 B。血培养阴性,无 DIC 证据,连续使用二性霉素 B 在11～20天(平均16天)。血小板低于20万则输血小板,共输40次。3例患者的血小板与供者血小板的 ABH 相容,平均接受了6个单位的血小板;1例为 ABH 及组织配型均相容,平均接受2个单位的血小板。血小板采集后保存在22℃8小时
Amphotericin B is a fungicidal polyene antibiotic, which has been clinically reported to cause thrombocytopenia. The reason is due to its inhibitory effect on bone marrow. The authors studied four patients with acute leukemia treated with amphotericin B. 3 cases of acute myeloid leukemia, 1 case of promyelocytic leukemia, are receiving anti-leukemia chemotherapy. It is prescribed that amphotericin B be used by patients who still have fever after 72 hours with antibiotics. Negative blood cultures without evidence of DIC continued use of amphotericin B for 11 to 20 days (mean, 16 days). Platelets less than 200,000 platelets were lost, a total of 40 times. Platelets from 3 patients were compatible with ABH from donor platelets, and received an average of 6 units of platelets. One patient was ABH and its tissue type was compatible with an average of 2 units of platelets. Platelets were stored at 22 ° C for 8 hours after collection