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美国儿科研究院建议,早产儿应在出生后2个月开始接种DTP。本研究结果支持了这一建议。作者对美国某医院1984年8月～1986年6月出生的110名早产儿和146名足月儿在出生后2、4和6个月分别接种DTP,在2、4、6和8月龄时采血检测免疫应答。用间接血凝法测定白喉和破伤风血清免疫应答;用百日咳杆菌凝集试验和中国仓鼠卵巢(CHO)细胞试验测定百日咳血清免疫应答。结果表明,(1)早产儿与足月儿的白喉保护性抗体滴度无显著性差异;(2)对破伤风类毒素的免疫应答与白喉略有不同,早产
The American Academy of Pediatrics recommends that premature babies start DTP inoculation 2 months after birth. The results of this study support this suggestion. The authors vaccinated 110 preterm infants and 146 full-term infants born at a U.S. hospital from August 1984 to June 1986 at 2, 4, and 6 months after birth and received DTP at 2, 4, 6, and 8 months of age Blood samples were taken to detect the immune response. Diphtheria and tetanus serum immune responses were measured by indirect hemagglutination assay; pertussis serum immune response was measured by pertussis bacilli agglutination test and Chinese hamster ovary (CHO) cell assay. The results showed that (1) there was no significant difference in the diphtheria protective antibody titers in preterm and full-term infants; (2) the immune response to tetanus toxoid was slightly different from diphtheria, and preterm labor