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目的探讨血小板源性生长因子(PDGF)和Ⅲ型前胶原氨基末端肽(PⅢNP)在尘肺病发生、发展中的意义。方法采用双抗体夹心法,测定77例尘肺病患者(包括32例矽肺、45例煤工尘肺)和77例健康对照者血清PDGF和PⅢNP的表达水平。结果尘肺病患者血清PDGF和PⅢNP含量分别为(36.31±3.31)ng/ml、(12.59±2.24)ng/ml,对照组则分别为(23.99±2.14)ng/ml、(9.33±2.63)ng/ml,差异均有统计学意义(P<0.05);矽肺患者血清PDGF和PⅢNP含量均高于煤工尘肺患者,差异有统计学意义(P<0.05);尘肺血清PDGF和PⅢNP呈线性关系且含量随着期别的增加而降低,差异有统计学意义(P<0.05)。结论尘肺病患者血清PDGF和PⅢNP含量可能与尘肺病的发生、发展有关,能否作为尘肺病血清生物标志物有待进一步探讨。
Objective To investigate the significance of platelet derived growth factor (PDGF) and type Ⅲ procollagen aminoterminal peptide (PⅢNP) in the occurrence and development of pneumoconiosis. Methods The serum levels of PDGF and PⅢNP in 77 patients with pneumoconiosis (including 32 patients with silicosis and 45 patients with coal worker’s pneumoconiosis) and 77 healthy controls were measured by double antibody sandwich method. Results The levels of serum PDGF and PⅢNP in patients with pneumoconiosis were (36.31 ± 3.31) ng / ml and (12.59 ± 2.24) ng / ml, while those in the control group were (23.99 ± 2.14) ng / ml and (P <0.05). The levels of PDGF and PⅢNP in patients with silicosis were significantly higher than those in coal workers with pneumoconiosis (P <0.05), and there was a linear relationship between the levels of PDGF and PⅢNP in pneumoconiosis With the increase of the stage decreased, the difference was statistically significant (P <0.05). Conclusion The serum levels of PDGF and PⅢNP in patients with pneumoconiosis may be related to the occurrence and development of pneumoconiosis. Whether they can be used as biomarkers of pneumoconiosis remains to be further explored.