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蛋白C系统是机体内肝素—AT—Ⅲ之外的又一重要抗凝系统,它主要通过对活化因子Ⅷ(Ⅷa)和活化因子Ⅴ(Ⅴa)的灭活而发挥强大的抗凝效应,其活性状态与机体许多疾病和病理过程密切相关。该系统自1976年被发现以来,在国外已受到了普遍的重视,并在基本明确其组成及各成分的生物学特性的基础上,发展了各种检测方法,较广泛的探讨了其临床意义。本文将就有关问题综述如下。一、蛋白C系统的生物学特性据目前所知,蛋白C系统由四种成份组成;蛋白C(Protein C,PC),蛋白S(Protein S.PS),活化蛋白抑制物(Activated Protein C Inhibi-tor,APCI)和血栓调节素(Thrombomoaulin,TM)。(一)蛋白C(PC)PC系由Stenflo(1976)首先发现,因其出现在DEAE-Sephadex色谱的第三峰(C峰)而被命名为PC。它是一种维生素K依
Protein C system is another important anticoagulant system besides heparin-AT-III in the body. It mainly exerts powerful anticoagulant effect through the inactivation of activated factor VIII (VIIIa) and activating factor V (Va). The active state is closely related to many diseases and pathological processes of the body. Since its discovery in 1976, the system has received widespread attention in foreign countries. Based on the basic definition of its composition and the biological characteristics of its components, various detection methods have been developed, and its clinical significance has been extensively explored. . This article will summarize the relevant issues as follows. First, the biological characteristics of protein C system According to current knowledge, Protein C system consists of four components; protein C (Protein C, PC), protein S (Protein S.PS), activated protein inhibitor (Activated Protein C Inhibi -tor (APCI) and Thrombomoaulin (TM). (a) Protein C (PC) PC was first discovered by Stenflo (1976) and was named PC because it appeared on the third peak (C peak) of the DEAE-Sephadex chromatogram. It is a kind of vitamin K.