论文部分内容阅读
目的探讨进展期胃癌组织中乳腺癌易感基因1(BRCA1)的表达及其与预后的关系。方法采用免疫组化方法检测637例进展期胃癌组织中BRCA1蛋白的表达,并分析患者预后情况。结果 219例(34.4%)胃癌组织中BRCA1蛋白表达阳性。BRCA1蛋白的表达与肿瘤分化程度相关(P<0.01)。单因素分析显示,BRCA1阳性表达患者生存时间长于阴性表达者(P<0.05);多因素分析显示,肿块大小、浸润深度、区域淋巴结转移、脉管神经侵犯及有无化疗是影响胃癌根治术后患者生存的独立预后因素(P<0.05)。结论 BRCA1阳性表达的胃癌患者预后较好,但BRCA1并非影响术后生存的独立预后因素。
Objective To investigate the expression of breast cancer susceptibility gene 1 (BRCA1) in advanced gastric cancer and its relationship with prognosis. Methods Immunohistochemistry was used to detect the expression of BRCA1 protein in 637 advanced gastric cancers and analyze the prognosis of the patients. Results The expression of BRCA1 protein was positive in 219 (34.4%) gastric cancer tissues. The expression of BRCA1 protein correlated with the degree of tumor differentiation (P<0.01). Univariate analysis showed that the survival time of patients with BRCA1 positive expression was longer than that of negative expression (P<0.05). Multivariate analysis showed that tumor size, depth of invasion, regional lymph node metastasis, vascular nerve invasion, and whether or not chemotherapy were effective in radical gastrectomy Independent prognostic factors in patients’ survival (P<0.05). Conclusion The prognosis of patients with gastric carcinoma positively expressed by BRCA1 is better, but BRCA1 is not an independent prognostic factor for postoperative survival.