论文部分内容阅读
目的制备醋酸曲安奈德(triamcinolone-acetonide-acetate,TAA)-聚乳酸(polylactic acid,PLA)植入剂(Im-plant),考察醋酸曲安奈德植入剂的体外释药特性。方法采用熔融-挤出法制备TAA-PLA植入剂,高效液相色谱法测定TAA含量,绘制体外释放曲线。结果制得的植入剂为直径0.8 mm,长约8 mm,质量约8 mg的白色柱状物,其中TAA的载药量为30%,体外释放速率平稳且缓慢,第30天时TAA的累积释放率为75.84%,药物体外释放符合Higuchi方程Q=0.137×(t-0.752)1/2。结论所制备的TAA-PLA植入剂对药物TAA有明显的缓释效果,且在体内可生物降解,毒副作用小,有望成为TAA的眼部新型给药制剂。
Objective To prepare the triamcinolone-acetonide-acetate (TAA) -lactic polylactic acid (PLA) implant and investigate the in vitro release characteristics of triamcinolone acetonide acetate. Methods TAA-PLA implants were prepared by melt-extrusion method. TAA content was determined by high performance liquid chromatography (HPLC) and the in vitro release curve was drawn. Results The obtained implants were white columns with a diameter of 0.8 mm, a length of 8 mm and a mass of about 8 mg. The TAA loading was 30%. The in vitro release rate was steady and slow. The cumulative release of TAA on the 30th day The rate was 75.84%. The drug release in vitro was in accordance with Higuchi’s equation Q = 0.137 × (t-0.752) 1/2. Conclusion The prepared TAA-PLA implants have obvious sustained release effect on the drug TAA, and are biodegradable in the body with little toxic or side effects. It is expected to be a novel ophthalmic preparation for TAA.