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目的前列腺素E1 治疗不稳定型心绞痛疗效观察。方法将61例不稳定型心绞痛患者随即分为2组 ,治疗组30例给予前列腺素E1;对照组31例给予硝酸甘油 ,两组疗程均为10d。观察症状改善情况、不良反应、用药前后心率、血压变化、血液流变仪测定红细胞最大变形指数及红细胞最大聚集指数。结果治疗组总有效率 (93.33% )高于对照组 (67.86 % ) ,红细胞最大变形指数增加了32.7 % ,红细胞最大聚集指数降低了19.3 % ,变化显著 ;而对照组变化无统计学意义。结论前列腺素E1 对不稳定型心绞痛有很好的治疗效果 ,副作用小 ,是值得探讨的一种治疗方法。
Objective To observe the efficacy of prostaglandin E1 in the treatment of unstable angina pectoris. Methods Sixty-one patients with unstable angina pectoris were randomly divided into two groups, 30 patients in the treatment group were treated with prostaglandin E1, and 31 patients in the control group were given nitroglycerin. The two courses of treatment were 10 days. Observed the improvement of symptoms, adverse reactions, heart rate before and after treatment, blood pressure changes, hematocrit measured the maximum deformation index of erythrocytes and erythrocyte maximum aggregation index. Results The total effective rate (93.33%) in the treatment group was significantly higher than that in the control group (67.86%), the maximum deformation index of erythrocytes increased by 32.7%, and the maximum erythrocyte aggregation index decreased by 19.3%, while the change of the control group was not statistically significant. Conclusions Prostaglandin E1 has a good therapeutic effect on unstable angina pectoris and has few side effects. It is worth to discuss a kind of treatment.