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一个国际研究团队使用干细胞成功培育出一个模仿人脑早期发育的3D结构。研究显示,这种“类脑器官(迷你大脑)”可以被用作微观分析人类遗传性疾病发病机理的模型系统。该研究由奥地利分子生物技术研究所的Juergen Knoblich牵头,并联合英国爱丁堡大学医学研究委员会(MRC)人类遗传小组的科学家共同开展,为搞清关于脑组织发育和神经疾病的人类特征提供了一种新的实验室方法,而这种方法恰恰是使用动物模型所无法实现的。为进行脑组织培养,研究人员利用干细胞自身形成复杂器官结构的能力研制了
An international research team using stem cells successfully bred a 3D structure that mimics the early development of the human brain. Studies have shown that this type of “brain (mini brain)” can be used as a model system for the microscopic analysis of the pathogenesis of human genetic diseases. The research, led by Juergen Knoblich of the Austrian Institute of Molecular Biotechnology and in collaboration with scientists from the Human Genetics Group at the Medical Research Council of Edinburgh, UK (MRC), provides a means of understanding the human characteristics of brain development and neurological disorders New laboratory method, and this method is precisely using animal models can not be achieved. For brain tissue culture, researchers developed the ability of stem cells to form their own complex organ architecture