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采用分子病理学检测技术,可将术后复发性肝癌(RHCC)分为两种主要类型,一种为单中心(单克隆)起源,属于残留复发;另一种为多中心(多克隆)起源,属于新生肿瘤。后者又可以再分为6种分子亚型,两种克隆型RHCC常以不同模式组合存在。根据区域癌化假说,还存在“第2区域肿瘤”的发生途径,由此RHCC的类型和发生机制可能更为复杂。正确判断RHCC的克隆起源对于临床提高RHCC个体化治疗水平具有实际的指导意义。为此,应重视建立适用性分子克隆诊断技术,为临床探讨RHCC的分类诊断和治疗路径提供指导依据。
Using molecular pathology, postoperative recurrent hepatocellular carcinoma (RHCC) can be divided into two main types, one of which is of single center (monoclonal) origin and belongs to residual relapse; the other is of multicentric (polyclonal) origin , Are newborn tumors. The latter can be subdivided into six molecular subtypes, two clonal RHCC often exist in different combinations of modes. According to the regional carcinogenesis hypothesis, there is also a “second area tumor” pathways, whereby the type and mechanism of RHCC may be more complicated. Correctly judging the clonal origin of RHCC is of practical significance in improving the individualized treatment of RHCC clinically. Therefore, attention should be paid to the establishment of molecular cloning diagnostic methods for clinical diagnosis of RHCC classification and treatment to provide guidance for the path.