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目的 探讨survivin和p53蛋白在子宫内膜样腺癌发生、发展中的作用。方法 通过免疫组化SP法检测49 例子宫内膜样腺癌石腊标本的survivin和p53蛋白表达。结果 子宫内膜样腺癌组和对照组survivin表达率分别为96％和 2.9％(P<0.01)。p53蛋白在对照组无表达,在子宫内膜样腺癌组13例表达阳性(26.5％),p53阳性率及表达强度与细胞 分化不良相关。结论 survivin表达与子宫内膜样腺癌发生有关,p53过表达提示细胞的恶性程度高和预后不良。
Objective To investigate the role of survivin and p53 in the occurrence and development of endometrial adenocarcinoma. Methods The expressions of survivin and p53 protein in 49 cases of endometrial adenocarcinoma paraffin specimens were detected by immunohistochemical SP method. Results The expression rates of survivin in endometrial adenocarcinoma group and control group were 96% and 2.9%, respectively (P <0.01). p53 protein was not expressed in the control group, 13 cases were positive in the endometrioid adenocarcinoma group (26.5%), the positive rate of p53 and the expression intensity were related to poor cell differentiation. Conclusion The expression of survivin is related to the occurrence of endometrial adenocarcinoma. Overexpression of p53 suggests that the malignant degree of the cell is high and the prognosis is poor.